Compare that with loading a multisample - almost automatic on the 606, but has to be done one-note-at-a-time on the 404, which I'm sure you'd agree is quite a bit slower! But it all depends on how you work and what you use the sampler for. I really love sound design, so the 606 is the best for me as it's by far the most powerful and flexible when it come to creating brand new noises!
It's like comparing PC and MAC - each is really just as easy to use, but not if you're not used to it