I am using the SP-606 with the P-606 software and I am having a little trouble with sampling loops I created with the software to the SP-606. What happens is when I make loops with the software and play it back with the software it sounds great but, when I sample it to the SP-606 and play it back the quality is slightly poor and a little distrorted. I tried lowering the levels but, still no luck.
Does anybody have any tips or tricks to help with this??

Perhaps your USB cable is broken? Perhaps your compact flash memory card in your SP is broken? Perhaps there's dust on the connections of your device (in this case in the USB output area perhaps?).

It could be many things though... even a virus scanner doing it's thing in the background could potentially ruin the signal quality.

Check in sp606 if you sampling in "Long" mode and change it to normal....sometimes in "long" mode my samples are distord when i have staff with ultra low frequencies or very high(like a violin)...the problem gets worse when resampling....
Also try changing in p606 the audio driver from asio to wdm or the opposite...

Thanks for your input I will check these things out and give you a update later.